| Basil Rathbone | Sherlock Holmes |
| Nigel Bruce | Doctor John H. Watson |
| Lionel Atwill | Professor James Moriarty |
| Kaaren Verne | Charlotte Eberli |
| William Post Jr. | Dr. Franz Tobel |
| Dennis Hoey | Inspector Beth Lestrade |
| Holmes Herbert | Sir Reginald Bailey |
| Mary Gordon | Mrs. Martha Hudson |
| Rudolph Anders | Braun |
| Whit Bissell | London Bobby Who Helps Dr. Tobel |
| Guy Kingsford | London Bobby |
| Henry Victor | Frederick Hoffner |
| Director | Roy William Neill |
| Producer | Howard Benedict |
| Writer | Edward T. Lowe Jr.; Scott Darling; Arthur Conan Doyle |
| Musician | Frank Skinner |
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