| Freddie Prinze Jr. | Fred Jones |
| Sarah Michelle Gellar | Daphne Blake |
| Matthew Lillard | Norville 'Shaggy' Rogers |
| Linda Cardellini | Velma Dinkley |
| Rowan Atkinson | Emile Mondavarious, Spooky Island Owner |
| Isla Fisher | Mary Jane |
| Miguel A. Núñez Jr. | Voodoo Maestro |
| Steven Grives | N' Goo Tuana |
| Charles Stan Frazier | Himself |
| Craig Bullock | Himself |
| Director | Raja Gosnell |
| Producer | Joseph Barbera; Sheryl Benko |
| Writer | William Hanna; Joseph Barbera |
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