| Chris Rock | Osmosis Jones |
| Laurence Fishburne | Thrax |
| David Hyde Pierce | Drix |
| Brandy Norwood | Leah |
| William Shatner | Mayor Phlegmming |
| Ron Howard | Tom Colonic |
| Kid Rock | Kidney Rock |
| Kenny Olson | Kidney Rock |
| Jason Krause | Kidney Rock |
| Joe C. | Kidney Rock |
| Director | Bobby Farrelly; Peter Farrelly |
| Producer | Dennis Edwards; Bobby Farrelly |
| Writer | Marc Hyman |
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